Complete nucleotide sequence of hepatitis B virus isolated from two infants with fulminant hepatitis.
نویسندگان
چکیده
Kenji Abe*, Tetsuya Kiuchi, Naoto Aiba, Huy Thien-Tuan Tran, Xin Ding, Mari Yamaguchi, Tetsutaro Sata and Koichi Tanaka Department of Pathology, National Institute of Infectious Diseases, Tokyo 162-8640, Department of Transplantation and Immunology, Kyoto University Faculty of Medicine, Kyoto 606-8501, Department of Developmental Medical Sciences, Graduate School of Medicine, University of Tokyo, Tokyo 113-0033 and PALMA Bee’Z Research Institute Co., Ltd., Kanagawa
منابع مشابه
Complete hepatitis B virus genome analysis in HBsAg positive mothers and their infants with fulminant hepatitis B
BACKGROUND After perinatal transmission of hepatitis B virus, infants of anti-HBe positive HBsAg carrier mothers may develop fulminant hepatitis B. Previously it has been suggested, that fulminant hepatitis B in adults was associated with specific mutations in the HBV-genome. The aim of this study was to investigate, whether specific viral variants are associated with fulminant hepatitis B in y...
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Abstract Background and objective: Hepatitis B virus (HBV) is a DNA virus with high tendency toward hepatic tissue. There are currently about 3 million HBV-infected people and 350 to 400 million chronic carriers of this virus in the world. X protein plays a role in the over-expression of oncogenes, carcinogenicity of liver cells and overlaps with the basal co...
متن کاملHepatitis B Virus Surface Antigen Variants Clustered Within Immune Epitopes in Chronic Hepatitis B Carriers from Hormozgan Province, South of Iran
Objective(s) The aim of this study was to characterize the hepatitis B virus surface protein genotypes and sequence variations among hepatitis B virus surface antigen (HBsAg) positive chronic patients in Hormozgan province, south of Iran. Materials and Methods A total of 8 patients enrolled in this study. The surface gene was amplified and directly sequenced. Genotypes and nucleotide/amino a...
متن کاملMutations in core nucleotide sequence of hepatitis B virus correlate with fulminant and severe hepatitis.
Infection with hepatitis B virus leads to a wide spectrum of liver injury, including self-limited acute hepatitis, fulminant hepatitis, and chronic hepatitis with progression to cirrhosis or acute exacerbation to liver failure, as well as an asymptomatic chronic carrier state. Several studies have suggested that the hepatitis B core antigen could be an immunological target of cytotoxic T lympho...
متن کاملIn Silico Prediction and Docking of Tertiary Structure of Multifunctional Protein X of Hepatitis B Virus
Hepatitis B virus (HBV) infection is a universal health problem and may result into acute, fulminant, chronic hepatitis liver cirrhosis, or hepatocellular carcinoma. Sequence for protein X of HBV was retrieved from Uniprot database. ProtParam from ExPAsy server was used to investigate the physicochemical properties of the protein. Homology modeling was carried out using Phyre2 server, and refin...
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ورودعنوان ژورنال:
- Japanese journal of infectious diseases
دوره 56 1 شماره
صفحات -
تاریخ انتشار 2003